EMPIAR-13731
Cryo-EM Structure of hERG Channel [multiple data sets in TIFF format]
Publication:

Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors

Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T

Structure (London, England : 1993) 32 (2024) 1926-1935.e3

PMID: 39321803

Related EMDB entry:
Deposited:
2026-04-22
Released:
2026-10-06
Last modified:
2026-10-06
Imageset size:
8.41 TB
Imageset DOI:
Experimental metadata:
Download xml json
Contains:
  • micrographs - multiframe
1. [EMD-60573] Cryo-EM Structure of inhibitor-free hERG Channel
Category:
micrographs - multiframe
Image format:
TIFF
No. of images or tilt series:
10184
Image size:
(5760, 4092)
Pixel type:
UNSIGNED BYTE
Pixel spacing:
(0.83, 0.83)
Details:
- Microscope: FEI TITAN Krios G3i
- Detector: Gatan K3 BIOQUANTUM
- Acceleration voltage (kV): 300
- The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value.
- Spherical aberration (Cs) : 2.7
- Nominal Defocus (μm): 1.8 - 1.0
- Average electron dose per image (e-/A2): 50
- Please use 'gain.tiff' as a gain reference without rotation and y-flipping.
Files:
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2. [EMD-60574] Cryo-EM Structure of astemizole-bound hERG Channel
Category:
micrographs - multiframe
Image format:
TIFF
No. of images or tilt series:
11658
Image size:
(5760, 4092)
Pixel type:
UNSIGNED BYTE
Pixel spacing:
(0.83, 0.83)
Details:
- Microscope: FEI TITAN Krios G3i
- Detector: Gatan K3 BIOQUANTUM
- Acceleration voltage (kV): 300
- The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value.
- Spherical aberration (Cs) : 2.7
- Nominal Defocus (μm): 1.8 - 1.0
- Average electron dose per image (e-/A2): 50
* Please use 'gain.tiff' as a gain reference without rotation and y-flipping.
Files:
Loading...
3. [EMD-60575] Cryo-EM Structure of E-4031-bound hERG Channel
Category:
micrographs - multiframe
Image format:
TIFF
No. of images or tilt series:
9711
Image size:
(5760, 4092)
Pixel type:
UNSIGNED BYTE
Pixel spacing:
(0.83, 0.83)
Details:
- Microscope: FEI TITAN Krios G3i
- Detector: Gatan K3 BIOQUANTUM
- Acceleration voltage (kV): 300
- The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value.
- Spherical aberration (Cs) : 2.7
- Nominal Defocus (μm): 1.8 - 1.0
- Average electron dose per image (e-/A2): 50
* Please use 'gain.tiff' as a gain reference without rotation and y-flipping.
Files:
Loading...
4. [EMD-60576] Cryo-EM Structure of pimozide-bound hERG Channel
Category:
micrographs - multiframe
Image format:
TIFF
No. of images or tilt series:
7658
Image size:
(5760, 4092)
Pixel type:
UNSIGNED BYTE
Pixel spacing:
(0.83, 0.83)
Details:
- Microscope: FEI TITAN Krios G3i
- Detector: Gatan K3 BIOQUANTUM
- Acceleration voltage (kV): 300
- The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value.
* Spherical aberration (Cs) : 2.7
- Nominal Defocus (μm): 1.8 - 1.0
- Average electron dose per image (e-/A2): 50
* Please use 'gain.tiff' as a gain reference without rotation and y-flipping.
Files:
Loading...
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