EMPIAR-13734 - Rabbit ryanodine receptor type 1 complexed with FKBP12.6, calmodulin, dantrolene, ATP, 4-chloro-m-cresol, and caffeine [5959 multi-frame micrographs composed of 40 frames each in TIFF format]

EMPIAR-13734

Rabbit ryanodine receptor type 1 complexed with FKBP12.6, calmodulin, dantrolene, ATP, 4-chloro-m-cresol, and caffeine [5959 multi-frame micrographs composed of 40 frames each in TIFF format]

Publication:

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB

bioRxiv (2024)

DOI: 10.1101/2024.10.21.619409

Related EMDB entry:

EMD-74303 EMD-74300 EMD-74445 EMD-74402 EMD-74401 EMD-74304 EMD-74302 EMD-74301

Deposited:

2026-06-22

Released:

2026-10-07

Last modified:

2026-10-07

Imageset size:

1.12 TB

Imageset DOI:

10.6019/EMPIAR-13734

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. Unaligned multi-frame micrographs of rabbit RyR1-FKBP12.6-CaM complex in the presence of dantrolene, ATP, 4-chloro-m-cresol, caffeine, and Mg2+

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

5959

Image size:

(3838, 3710)

Pixel type:

UNSIGNED 16 BIT INTEGER

Pixel spacing:

(1.06, 1.06)

Details:

Please use data/gain_reference_RyR1_DanATP.mrc with a Y-flip when importing into CryoSPARC. Particle images are located in data/particles. Particle positions, CTF estimations, and 3D alignments are described in the data/particles/RyR1_DanATP_particles.star text file.

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Citations

Post-acquisition super resolution for cryo-electron microscopy.

Burton Smith RN, Murata K. (2026)

Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph

Watanabe R, Lee EB. (2026)

Ligand-induced activation of RyR1 in native membranes.

Mikirtumov V, Golusik S, Huo R, Sprink T, Balyschew N, Yang W, Diebolder C, Yuan S, Kotecha A, Kudryashev M. (2026)

QwenCryoMarker: a universal post-processing framework for contamination-aware particle cleaning.

Sun Y, Zhao J, Xu N, Wang L, Ding W, Li M. (2026)

CryoMV: Structure-Prior-Guided Modeling and Real-Particle Validation of Continuous Conformational Transitions in Cryo-EM

Li F, Dong H, Tang S, Wang X, Zhang C, Ji C, Han R, Zhang F, Wan X. (2026)

An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM.

Marchán Torres D, Conesa P, Garcia A, Iceta M, Broche L, Gragera M, Linares R, Kwong HS, Chichón FJ, Svensson O, Arranz R, Effantin G, Kandiah E, Carazo JM, Sorzano COS. (2026)

AlignPCA-2D: PCA-reduced Euclidean vector alignment for 2D classification in cryo-EM.

Ramírez-Aportela E, Zarrabeitia OL, Fonseca YC, Ceska T, Subramaniam S, Carazo JM, Sorzano COS. (2026)

A variational framework with composite sparse regularization for cryo-electron tomography reconstruction.

Yu C, Xu Z, Zeng Q, Wan X, El-Messiry H, Zhang F, Han R. (2026)

Helical reconstruction of amyloids in cryoSPARC.

Schaefer JH, O'Neill RT, Donnelly JP, Powers ET, Kelly JW, Lander GC. (2026)

CryoFSL: an annotation-efficient, few-shot learning framework for robust protein particle picking in cryo-electron microscopy micrographs.

Poudel B, Gyawali R, Dhakal A, Cheng J, Xu D. (2026)

See all citations

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[2026-10-07]

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