EMPIAR-12623 - Cryo-EM structure of human MPC in complex with TZD [7457 multi-frame micrographs composed of 40 frames each in TIFF format]

EMPIAR-12623

Cryo-EM structure of human MPC in complex with TZD [7457 multi-frame micrographs composed of 40 frames each in TIFF format]

Publication:

Structure of mitochondrial pyruvate carrier and its inhibition mechanism

He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L

Nature (2025)

PMID: 40044865

DOI: 10.1038/s41586-025-08667-y

Related EMDB entry:

EMD-48441

Deposited:

2025-02-28

Released:

2025-06-03

Last modified:

2025-06-03

Imageset size:

3.36 TB

Imageset DOI:

10.6019/EMPIAR-12623

Experimental metadata:

Download xml json

Contains:

micrographs - multiframe

Image Sets

1. unaligned multi-frame micrographs of human MPC in complex with TZD

Category:

micrographs - multiframe

Image format:

TIFF

No. of images or tilt series:

7457

Image size:

(11520, 8184)

Pixel type:

UNSIGNED BYTE

Pixel spacing:

(0.86, 0.86)

Details:

---

Files:

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Citations

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles

Kim K, Li H, Clarke OB. (2025)

Self-supervised learning for generalizable particle picking in cryo-EM micrographs.

Zamanos A, Koromilas P, Bouritsas G, Kastritis PL, Panagakis Y. (2025)

In situ structure determination of conformationally flexible targets using nextPYP.

Liu HF, Zhou Y, Huang Q, Martin J, Bartesaghi A. (2025)

CryoPROS: Correcting misalignment caused by preferred orientation using AI-generated auxiliary particles.

Zhang H, Zheng D, Wu Q, Yan N, Peng H, Hu Q, Peng Y, Yan Z, Shi Z, Bao C, Hu M. (2025)

Few-shot learning for non-vitrified ice segmentation.

Vivas-Lago A, Castaño-Díez D. (2025)

Automated removal of corrupted tilts in cryo-electron tomography.

Majtner T, Turoňová B. (2025)

Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries.

Felix J, De Munck S, Bazan JF, Savvides SN. (2025)

Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE.

Van CTS, Reboul CF, Caesar JJE, Meana-Pañeda R, Lountos GT, Deme JC, Bryant OJ, Johnson S, Piczak CT, Valkov E, Lea SM, Elmlund H. (2025)

Cryo-EM Structure Reconstruction by Gaussian Splatting: Pushing the Resolution to Extreme

Zeng B, Liu S, Cheng S, Xu G, Fan H. (2025)

Molecular exaptation by the integrin αI domain.

Hollis JA, Chan MC, Malik HS, Campbell MG. (2025)

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