EMPIAR-11191 - cryoEM structure of Gq-coupled MRGPRX1 with Compound-16 [3281 micrographs in MRC format]

EMPIAR-11191

cryoEM structure of Gq-coupled MRGPRX1 with Compound-16 [3281 micrographs in MRC format]

Publication:

Ligand recognition and allosteric modulation of the human MRGPRX1 receptor

Liu Y, Cao C, Huang XP, Gumpper RH, Rachman MM, Shih SL, Krumm BE, Zhang S, Shoichet BK, Fay JF, Roth BL

Nature chemical biology (2022)

PMID: 36302898

DOI: 10.1038/s41589-022-01173-6

Related EMDB entry:

EMD-27753 EMD-27752 EMD-27754

Deposited:

2022-08-30

Released:

2022-10-31

Last modified:

2022-10-31

Imageset size:

309.33 GB

Imageset DOI:

10.6019/EMPIAR-11191

Experimental metadata:

Download xml json

Contains:

micrographs - single frame

Image Sets

1. Aligned multi-frame micrographs

Category:

micrographs - single frame

Image format:

MRC

No. of images or tilt series:

3281

Image size:

(5760, 4092)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(0.88, 0.88)

Details:

The micrographs are dose weighted motion corrected with a total electron exposure of 43.8e/A2

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Citations

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles

Kim K, Li H, Clarke OB. (2025)

CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy.

Krentzel D, Elphick M, Domart MC, Peddie CJ, Laine RF, Shand C, Henriques R, Collinson LM, Jones ML. (2025)

PERC: a suite of software tools for the curation of cryoEM data with application to simulation, modeling and machine learning.

Costa-Gomes B, Greer J, Juraschko N, Parkhurst J, Mirecka J, Famili M, Rangel-Smith C, Strickson O, Lowe A, Basham M, Burnley T. (2025)

Self-supervised learning for generalizable particle picking in cryo-EM micrographs.

Zamanos A, Koromilas P, Bouritsas G, Kastritis PL, Panagakis Y. (2025)

Laser flash melting cryo-EM samples to overcome preferred orientation.

Straub MS, Harder OF, Mowry NJ, Barrass SV, Hruby J, Drabbels M, Lorenz UJ. (2025)

In situ structure determination of conformationally flexible targets using nextPYP.

Liu HF, Zhou Y, Huang Q, Martin J, Bartesaghi A. (2025)

EMICSS: added-value annotations for EMDB entries.

Duraisamy AK, Fonseca N, Kleywegt GJ, Patwardhan A, Morris KL. (2025)

Global conformations of <i>Pichia pastoris</i> complex I are distinguished by the binding of a unique interdomain bridging subunit.

Lee CS, Grba DN, Wright JJ, Ivanov BS, Hirst J. (2025)

Overcoming Preferred Orientation in Cryo-EM With Ultrasonic Excitation During Vitrification

Williams HM, Curtis WA, Haubner M, Hruby J, Drabbels M, Lorenz UJ. (2025)

Disulfide-constrained Fabs overcome target size limitation for high-resolution single particle cryoEM.

Kung JE, Johnson MC, Tegunov D, Jao CC, Wu P, Oh A, Lin M, Daria JM, Koth CM, Arthur CP, Rohou A, Sudhamsu J. (2025)

See all citations

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