EMPIAR-11665 - Atomic structure and conformational variability of the HER2-trastuzumab-pertuzumab complex [stack of 708609 particles in MRCS format]

EMPIAR-11665

Atomic structure and conformational variability of the HER2-trastuzumab-pertuzumab complex [stack of 708609 particles in MRCS format]

Publication:

Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex

Ruedas R, Vuillemot R, Tubiana T, Winter JM, Pieri L, Arteni AA, Samson C, Jonic S, Mathieu M, Bressanelli S

Journal of structural biology 216 (2024)

PMID: 38723875

DOI: 10.1016/j.jsb.2024.108095

Related EMDB entry:

EMD-17993 EMD-18188 EMD-18190 EMD-18189

Deposited:

2023-06-13

Released:

2024-06-13

Last modified:

2024-06-13

Imageset size:

222.47 GB

Imageset DOI:

10.6019/EMPIAR-11665

Experimental metadata:

Download xml json

Contains:

picked particles - multiframe - processed

Image Sets

1. Aligned particles images of the flexible HER2-Trastuzumab-Pertuzumab ternary complex

Category:

picked particles - multiframe - processed

Image format:

MRCS

No. of images or tilt series:

708609

Image size:

(280, 280)

Pixel type:

32 BIT FLOAT

Pixel spacing:

(1.16, 1.16)

Details:

This the particle stack for the global reconstruction of the flexible HER2-Trastuzumab-Pertuzumab ternary complex. It allows reconstruction to an overall resolution < 3.3 A. The data sign is +1, white particle on dark background. The accompanying star file is exported from the last round of global refinement in cryoSPARC v. 4.1.2, with all the CTF parameters recorded. The dataset displays considerable continuous conformational variability.

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Citations

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